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Ceftriaxone Sodium & Tazobactam Sodium for Injection 3375mg

Ceftriaxone Sodium and Tazobactam Sodium 3375mg Veterinary Injection

Composition: Each vial contains:

  • Ceftriaxone Sodium 3000 mg
  • Tazobactam Sodium 375 mg

Pharmacology:

  • Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum bactericidal activity. It interferes with the bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and bacterial death. Ceftriaxone is effective against both Gram-positive and Gram-negative bacteria.
  • Tazobactam is a β-lactamase inhibitor that protects ceftriaxone from degradation by β-lactamase enzymes produced by certain bacteria. This enhances the effectiveness of ceftriaxone against resistant organisms, including those that produce β-lactamase.

The combination of ceftriaxone and tazobactam provides an extended spectrum of activity, especially against resistant pathogens.

Indications: This veterinary injection is indicated for the treatment of a wide range of bacterial infections in animals caused by susceptible organisms, including:

  • Respiratory infections (e.g., pneumonia, bronchitis)
  • Urinary tract infections (e.g., cystitis, pyelonephritis)
  • Soft tissue infections (e.g., abscesses, wound infections)
  • Intra-abdominal infections (e.g., peritonitis, abscesses)
  • Bone and joint infections (e.g., osteomyelitis, septic arthritis)
  • Sepsis and systemic infections

It is effective for use in various animal species, including dogs, cats, and livestock.

Dosage and Administration:

  • For dogs and cats: Administer the injection either intramuscularly (IM) or intravenously (IV).
    • Typical dosage: 20-40 mg/kg body weight per day, depending on the severity of the infection.
    • The injection is typically given once a day, and treatment can continue for 5-10 days or as directed by a veterinarian.
  • For livestock: The exact dosage should be determined by the attending veterinarian, taking into consideration the species, weight, and condition of the animal.

Contraindications:

  • Do not use in animals with a known hypersensitivity to ceftriaxone, tazobactam, penicillins, cephalosporins, or any other component of the formulation.
  • Use with caution in animals with compromised renal or hepatic function.

Warnings:

  • For veterinary use only. Not intended for animals that will be slaughtered for human consumption.
  • Overdose may cause adverse effects, such as gastrointestinal upset or neurological symptoms. Follow the veterinarian's guidance on dosage.
  • This product should only be used under the supervision of a veterinarian.

Side Effects:

  • Common side effects include:
    • Gastrointestinal disturbances such as mild diarrhea or vomiting.
    • Local reactions at the injection site, such as pain, swelling, or irritation.
  • Rare side effects include:
    • Allergic reactions such as rashes, fever, or difficulty breathing.
    • Hematological abnormalities like leukopenia (low white blood cell count) or thrombocytopenia (low platelet count).
    • Elevations in liver enzymes or signs of liver dysfunction, especially in animals with pre-existing liver conditions.
    • Renal issues may occur in animals with kidney impairment.

Storage:

  • Store in a cool, dry place, away from direct sunlight.
  • Do not freeze the vial.
  • Once the vial is opened, use within the recommended time frame.
  • Keep out of reach of children and animals.

Precautions:

  • Complete the entire course of treatment as prescribed by the veterinarian, even if symptoms improve, to avoid the development of antibiotic resistance.
  • Monitor kidney and liver function in animals receiving prolonged treatment or those with pre-existing renal or hepatic conditions.
  • Use this medication only as directed by a veterinarian to prevent misuse or overuse, which could contribute to resistance.

 

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