Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity against both Gram-positive and Gram-negative bacteria. It works by binding to penicillin-binding proteins (PBPs) and inhibiting bacterial cell wall synthesis, resulting in bacterial cell death.
Tazobactam is a β-lactamase inhibitor that works synergistically with ceftriaxone by inhibiting the action of bacterial β-lactamases, enzymes that can inactivate cephalosporins. This combination allows ceftriaxone to maintain its activity against β-lactamase-producing resistant organisms.
This combination enhances the antimicrobial activity of ceftriaxone, particularly against resistant bacteria that produce β-lactamase.
Indications: This veterinary injection is used to treat infections in...
Ceftriaxone Sodium and Tazobactam Sodium 1125mg Veterinary Injection
Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity against both Gram-positive and Gram-negative bacteria. It works by binding to penicillin-binding proteins (PBPs) and inhibiting bacterial cell wall synthesis, resulting in bacterial cell death.
Tazobactam is a β-lactamase inhibitor that works synergistically with ceftriaxone by inhibiting the action of bacterial β-lactamases, enzymes that can inactivate cephalosporins. This combination allows ceftriaxone to maintain its activity against β-lactamase-producing resistant organisms.
This combination enhances the antimicrobial activity of ceftriaxone, particularly against resistant bacteria that produce β-lactamase.
Indications: This veterinary injection is used to treat infections in animals caused by susceptible bacteria. Indications include:
Respiratory infections (pneumonia, bronchitis)
Urinary tract infections (cystitis, pyelonephritis)
Soft tissue infections (wound infections, abscesses)
Intra-abdominal infections (peritonitis, abscesses)
Bone and joint infections (osteomyelitis, septic arthritis)
Sepsis and systemic infections
It is suitable for use in a variety of animals, including dogs, cats, and livestock.
Dosage and Administration:
For dogs and cats: Administer the injection intramuscularly or intravenously.
Standard dosage: 20-40 mg/kg body weight per day, depending on the severity of the infection.
The injection can be given once a day, with the total course of treatment lasting 5-10 days or as advised by the veterinarian.
For livestock: The dosage is species-specific and should be determined by the veterinarian, based on the weight and clinical condition of the animal.
Contraindications:
Do not use in animals with a known hypersensitivity to ceftriaxone, tazobactam, penicillins, cephalosporins, or any component of the formulation.
Caution is advised in animals with renal or hepatic impairment.
Warnings:
For veterinary use only. Not intended for use in animals that will be slaughtered for human consumption.
Overdose or improper administration can cause adverse reactions, such as gastrointestinal upset or neurological symptoms.
Always consult a veterinarian for the proper diagnosis, treatment regimen, and dosage adjustment.
Side Effects:
Common side effects may include:
Mild gastrointestinal symptoms such as diarrhea or vomiting.
Local reactions at the injection site, such as pain, swelling, or inflammation.
Rare side effects may include:
Allergic reactions like skin rashes, fever, or difficulty breathing.
Changes in blood cell counts, including leukopenia or thrombocytopenia.
Liver enzyme elevations or renal dysfunction (especially in animals with pre-existing kidney or liver disease).
Storage:
Store the vial in a cool, dry place away from direct sunlight.
Do not freeze the product. Once opened, use within the recommended time frame.
Keep out of reach of children and animals.
Precautions:
Ensure that the entire course of treatment is completed to prevent the development of antibiotic resistance.
Regular monitoring is advised for animals with compromised liver or kidney function during the course of treatment.
Avoid overuse of antibiotics, as this can lead to resistance and treatment failure.
Conclusion: The combination of Ceftriaxone Sodium and Tazobactam Sodium in the 1125 mg veterinary injection is an effective treatment option for a variety of bacterial infections in animals. It is particularly beneficial for treating infections caused by β-lactamase-producing organisms, which are often resistant to many other antibiotics. The drug’s broad spectrum and the synergy between the two components make it a valuable tool in veterinary medicine for managing serious bacterial infections across different animal species.